Monitoring T cell repertoires by next generation sequencing (NGS) following Treg infusion (WP4)

  • Workpackage leader
  • Participants
  • Objectives of the Workpackage
    • To monitor the fate of infused Treg cells using next generation sequencing of T cell receptor beta chain (TCRB) transcripts
    • To profile naive and memory Treg, Tcon and CD8+ T cellsubsets in the infused product, as well as in the recipient's peripheral blood pre- and post-infusion
    • To monitor TCR alpha/beta chain combinatorics and ascertain the role of chain combination in clearing of infused T cells from circulation

About the clinical trial

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